5-Prime | Nonribosomal Peptide Synthesis What is it? As the name suggests, nonribosomal peptide synthesis (NRPS) generates polypeptides sans ribosome. The resultant peptides, generally short oligomers ...

Scientists from McGill University have discovered how certain microbes create powerful drugs such as antibiotics and cancer treatments. Their surprising findings could transform the way ...

Colistin is a multicomponent polypeptide antibiotic that is mainly composed of colistin A and colistin B. PMB and colistin (polymyxin E) are secondary metabolite nonribosomal peptides that share a ...

More information: Yaoyu Ding et al, Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases, Journal of the American Chemical Society (2024). DOI: 10.1021/jacs ...

This University of California, San Diego, advance will finally enable scientists to rapidly characterize ring-shaped nonribosomal peptides -- a class of natural compounds of intense interest due ...

“Using a molecule-centered approach and computational techniques, we first predicted the nonribosomal peptide synthetase assembly line of paleomycin, the ancestral parent of lipid II targeting GPAs.

The company hoped to use the bacteria to more efficiently make a precursor for one of its HIV protease inhibitors, Crixivan. While analyzing the Rhodococcus genome, the MIT researchers were surprised ...

Some are formed of cyclic peptides – strings of amino acids joined together in a circle ... Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases.

Rapid Peptide Cyclization Inspired by the Modular Logic of Nonribosomal Peptide Synthetases. Journal of the American Chemical Society , 2024; DOI: 10.1021/jacs.4c04711 Cite This Page : ...