Nitrosoureas This barrier protects the brain from many substances in the body. However, getting through the blood-brain barrier is important for treating some cancers, including brain cancer.

Nitrosoureas A group of alkylating drugs called nitrosoureas has a unique ability to reach the brain. These agents can cross the blood-brain barrier, which keeps most drugs and many other toxic ...

Systematic review and meta-analysis of the efficacy of nitrosoureas (Amarasingh et al, 2009) and gene therapy (Conlin, unpublished observations) for experimental glioma models have shown some ...

Nitrosoureas The chloroethylnitrosoureas—streptozocin, methyl-CCNU (semustine), carmustine (BCNU), and lomustine (CCNU)—cause slow, progressive, generally irreversible renal dysfunction.

Methods: Patients with GBM who failed the standard Stupp regimen have been treated with a nitrosoureas based regimen of fotemustine (FTM) 75-100mg/sqm at day 1, 8, 15 (induction phase) and after 4/5 ...

Evaluation of expression of DNA repair molecules as a prognostic factor for long-term survivors with glioblastoma multiforme (GBM) treated on RTOG protocols with irradiation and nitrosoureas C. Ford , ...