To that end, they engineered CAR T 5T IF and 4T IF cells to make them secrete a IL-4 mutein known to block IL-4 and IL-13 signaling. They then injected the results into mice with induced human ...

Checkpoint inhibitors, CAR-T cells, modified TCR T cells ... Starting with a highly immunodeficient mouse [the NCG platform], we use radiation to deplete its immune system even further.

In cultures of both human cells and living mice, engineered regulatory T cells were able to simmer down gluten-reactive effector T cells that cause the characteristic autoimmune response seen in ...

while mice with these cells did not. An analysis of the gut immune cells found an imbalance among the T cells that trigger ...

Sponsored content brought to you by In the rapidly advancing field of immuno-oncology research, there has been increasing ...

CD8 T cells lacking Tet1/3 preferentially differentiate into short-lived effector and effector memory cells following acute ...

Study in mice identifies essential immune cells in the intestine that help to prevent unwarranted reactions to harmless food allergens.