Morphine and cocaine both lead to addiction in part because of how they affect key reward areas in the brain. But a new study shows that they do this in very different ways -- knowledge that may ...

The availability of nalorphine,§ an effective morphine antagonist, has allowed a new approach to the problem of the mechanism by which this increase in intracranial pressure occurs.

The stimulatory effect of morphine was abrogated by β-FNA, indicating an MOR-mediated mechanism. Conclusion. Morphine stimulates CCL2 production by human neurons via a MOR-related mechanism. This ...

Find patient medical information for Morphine on WebMD including its uses, side effects and safety, interactions, pictures, ... How does morphine work (mechanism of action)?

Furthermore, we demonstrated that the learned compensatory mechanism contributing to associative morphine tolerance requires an action of CCK at the CCK-B receptor in the L/BL amygdala. METHODS ...

Find patient medical information for Morphine on WebMD including its uses, side effects and safety, interactions, pictures, warnings, and user ratings ...

A team of Brown University scientists found that morphine disrupts an inhibitory mechanism in the ventral tegmental area (VTA), a cluster of neurons in the center of the brain responsible for ...

The authors concluded that "the percentage who used only a 'weaker-than-morphine-opioid' in the past 30 days declined from 42.4% in 1999-2002 to 20% in 2011-2012, while the percentage who used a ...

Morphine and other opioids are vital to treat severe and chronic pain. However, they have two problems — prolonged use creates morphine tolerance, where ever-increasing doses are needed for the same ...

The principal therapeutic action of morphine is analgesia. The precise mechanism of action is not known but the effects are thought to be mediated through opioid-specific receptors located in the CNS.

The use of morphine during early resuscitation and trauma care was significantly ... P<0.001). This association remained significant after adjustment for injury severity, age, mechanism of ...