HK) presented the mechanism of action (MOA) research findings of its innovative bispecific antibody, AK132, targeting both Claudin18.2 (CLDN18.2) and CD47. AK132 is an asymmetric bispecific ...

Thus, this engineering approach will be a useful tool for design of IgG antibodies with tailored mode-of-action towards a specific target and indication. "Development of the next generation of ...

Enumeral is further investigating the mechanism of action of these differentiated antibodies, and has initiated testing in immuno-humanized mouse models of cancer, which enable testing of PD-1 ...

a bispecific antibody targeting EGFR and LGR5, in the journal "Cancers." The study highlights the mechanism of action of petosemtamab, which is designed to combat cancer by blocking EGFR ligands ...

Interleukin (IL)-15 is a cytokine with different modes of action ... of clinical testing of humanized anti-IL-15 monoclonal antibodies. "IL-15 is an ambivalent cytokine, and understanding its ...

Studies have reported that COVID-19 vaccines confer immune protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by inducing antibody (Ab)-based humoral and T ...

Merus N.V. (Nasdaq: MRUS) (“Merus”, “the Company”, “we”, or “our”), an oncology company developing innovative, full-length multispecific antibodies and antibody drug conjugates (Biclonics®, ...

The whole P-cadherin/antibody/drug complex is then sent to a structure called the lysosome to be broken down. “Our results establish an outside-in signaling mechanism that provides fundamental ...