Figure 4: Model for the contribution of Eg5 to mitotic spindle morphogenesis. We anticipate our assay to be a starting point for more sophisticated in vitro models of mitotic spindles. For example ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

Mitotic spindles are dynamic, self-organizing, intracellular structures that are essential for cell division. Spindles are composed of proteins, cytoskeletal elements and microtubules, which are a key ...