Figure 1: Clathrin was targeted to the mitotic spindle of NRK cells. Figure 2: Clathrin was targeted to the mitotic spindle via the N-terminal domain of the heavy chain. Does prolonged mitosis in ...

Impairment of spindle checkpoint function results in premature mitosis and missegregation of chromosomes, leading to aneuploidy (Michel et al., 2001). The signal activating spindle checkpoint is ...

The findings, published in Developmental Cell, help to elucidate the function of these tiny cellular structures in mitosis. Correct mitosis requires the formation of a filamentous spindle that ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

Mitotic spindles use an elegant bipolar architecture to segregate ... By varying the features of our model, we identify a set of functions essential for the generation and stability of spindle ...

The mitotic spindle includes thousands of microtubules ... the team tracked their activity and discovered that this force is a function of the microtubule overlap—the longer the overlap ...

The mitotic spindle includes thousands of microtubules ... the team tracked their activity and discovered that this force is a function of the microtubule overlap—the longer the overlap, the greater ...

Kinesins have a wide range of functions including transporting structures ... cytoplasmic dynein is vital to mitosis and the positioning of the mitotic spindle. Cilia and flagella are projections ...

regulation of MT overlaps is important for mitotic spindle function and cytokinesis. We are studying the density of motors on antiparallel microtubule overlaps and subsequent length regulation of the ...

Blocking gene essential to supporting Myc-driven cancers leads to tumor regression in vivo. Inhibiting SUMOylation in Myc oncogene-carrying tumor cells could represent a new approach to treating ...