Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

The spindle functions not only to segregate the replicated chromosomes into separate nuclei (karyokinesis), but also ensures that a furrow or cell plate is formed to partition the cytoplasm ...

HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

Without centromeres, cells cannot divide properly and the overall process of mitosis fails. Why are these small chromosomal regions so essential to such a major cellular process? With a few ...

During mitosis, spindle microtubules capture the kinetochore formed in the centromere. After mitosis, chromosomes are divided into daughter cells. Disclaimer: AAAS and EurekAlert! are not ...

In organisms like yeast, spindle pole bodies (SPBs) function similarly but lack centrioles. The SPBs, embedded in the nuclear membrane, orchestrate spindle dynamics during the closed mitosis ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...