HDAC6 is upregulated in corneal diseases and causes ENKD1 deacetylation at lysine 98. Deacetylation of ENKD1 blocks its ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

microtubule-based mitotic spindle is assembled de novo. The spindle functions not only to segregate the replicated chromosomes into separate nuclei (karyokinesis), but also ensures that a furrow ...

In electron micrographs of mitotic ... functions involve microtubules (e.g., microtubule attachment, polymerization, and motor-directed movements). Other kinetochore proteins are part of the ...

During mitosis, spindle microtubules capture the kinetochore formed in the centromere. After mitosis, chromosomes are divided into daughter cells. Disclaimer: AAAS and EurekAlert! are not ...

function similarly but lack centrioles. The SPBs, embedded in the nuclear membrane, orchestrate spindle dynamics during the closed mitosis typical of these species. The malaria parasite ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...