Figure 1: Clathrin was targeted to the mitotic spindle of NRK cells. Figure 2: Clathrin was targeted to the mitotic spindle via the N-terminal domain of the heavy chain. Does prolonged mitosis in ...

Impairment of spindle checkpoint function results in premature mitosis and missegregation of chromosomes, leading to aneuploidy (Michel et al., 2001). The signal activating spindle checkpoint is ...

The findings, published in Developmental Cell, help to elucidate the function of these tiny cellular structures in mitosis. Correct mitosis requires the formation of a filamentous spindle that ...

Mitotic spindles use an elegant bipolar architecture to segregate ... By varying the features of our model, we identify a set of functions essential for the generation and stability of spindle ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

Kinesins have a wide range of functions including transporting structures ... cytoplasmic dynein is vital to mitosis and the positioning of the mitotic spindle. Cilia and flagella are projections ...

The mitotic spindle includes thousands of microtubules ... the team tracked their activity and discovered that this force is a function of the microtubule overlap—the longer the overlap ...

Blocking gene essential to supporting Myc-driven cancers leads to tumor regression in vivo. Inhibiting SUMOylation in Myc oncogene-carrying tumor cells could represent a new approach to treating ...

The mitotic spindle includes thousands of microtubules ... the team tracked their activity and discovered that this force is a function of the microtubule overlap—the longer the overlap, the greater ...

Kinesin-5 proteins and microtubules are important components of the mitotic spindle, which segregates chromosomes in dividing cells. In a shop run by Tarun Kapoor, Ph.D., Rockefeller scientists ...

New findings from his lab published in the July 21 advance online issue of Nature demonstrate that the way the mitotic spindle—the machinery that separates chromosomes into daughter cells during ...