Spindle fibers form a protein structure that divides the ... During mitosis, the spindle fibers are called the mitotic spindle. Meanwhile, during meiosis, the spindle fibers are referred to ...

Protein formations called kinetochores form around the centromere. The mitotic spindle extends from the poles and attaches to the kinetochores. During metaphase, the microtubules pull the sister ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

More information: Cecilia Aquino-Perez et al, FAM110A promotes mitotic spindle formation by linking microtubules with actin cytoskeleton, Proceedings of the National Academy of Sciences (2024).

In mammals, several NEKs—including NEK2, NEK6, NEK7, and NEK9—localize to centrosomes, the microtubule-organizing centers (MTOCs) responsible for forming the mitotic spindle. These centrosomes ...