the functional perturbation of which makes mitotic spindle poles susceptible to the action of spindle- and chromosome-mediated forces leading to irreversible multipolar spindle formation.

S2g). Taken together, these data suggest that Kin-1 itself is a PCM protein and, as such, may have a critical role in mitotic spindle formation. Figure 3: Kin-1 localization at centrosomes and its ...

Cell division is essential to the propagation of life. During cell division, mitotic spindles segregate duplicated chromosomes with high fidelity. Spindle structure depends on the proper polar ...

The antimitotic properties of parthenolide, a natural compound with known anticancer activity, have been largely ...

The mitotic spindle, an apparatus that segregates chromosomes ... Mazur and his colleagues demonstrated that the microtubules can begin to form throughout the spindle. They also vary in length ...

The mitotic spindle includes thousands of microtubules ... they become the governing force of the spindle formation. “This work represents an important advance in our efforts to build, from ...

When cells divide, microtubules -- a dynamic network of protein filaments -- form a mitotic spindle that draws the chromosomes apart and arranges them into two daughter cells. Here, plants and ...

Many millions of times per day, football-shaped structures called mitotic spindles form within the body’s cells as they prepare to divide. The process is routine but mysterious, as the micro-mechanics ...

Events characteristic of cell division — the formation of the mitotic spindles, the formation of contractile rings, karyokinesis, and cytokinesis — were identified; these features demonstrated ...