Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. The exact mechanism of action of metoclopramide in the ...

Box 1 Pharmacology and mechanism of action of metoclopramide. Metoclopramide is a mixed D1/D2 dopamine-receptor-blocking drug.

Metoclopramide is currently the only medication that is US FDA approved for the treatment of gastroparesis. [] It was first described by Louis Justin-Besaçon and Charles Laville in 1964 and has ...

The mechanism of sedative action of metoclopramide may be the result of a central antidopaminergic effect that metoclopramide exerts by antagonizing dopamine D2 receptors 11.