For initial treatment of symptomatic pulmonary sarcoidosis, methotrexate appeared to work as well as prednisone over 24 weeks, the randomized PREDMETH trial showed. Mean change from baseline in the ...

Doctors may prescribe either medication as an alternative to methotrexate. Taking DMARDs to treat PsA is also an off-label use. DMARDs can take several weeks or months to have a noticeable effect.

The FDA and Health Canada "should also consider issuing warning labels to inform prescribers of the study's findings," the researchers wrote. Methotrexate is commonly prescribed for rheumatoid ...

Methotrexate is a cheap ... Yet few are aware that it is used off-label to end ectopic pregnancies, or that it could be restricted by doctors or pharmacists even in states like Virginia that ...

Sometimes methotrexate is used off-label to end ectopic pregnancies, and use while pregnant can cause miscarriages or birth defects. Women with RA in states with restrictive abortion laws are now ...

Patients who take methotrexate for a variety of immune-mediated ... they reported results from a randomized, open-label, superiority trial that suggested pausing the drug improved immunogenicity ...

Methotrexate has also been used off-label in the treatment of miscarriage and ectopic pregnancy, and it can be combined with misoprostol to induce abortion in early pregnancy. 4,6 Because ...

JCOG0905 is a multicenter, open-label, randomized trial conducted in Japan ... MAPIF therapy including six courses of IF and MAP with doxorubicin reduced to 57% and methotrexate to 80% to balance ...

The label expansion, announced Friday, combines Krystexxa with the chemotherapy and immunosuppressive drug methotrexate. In a randomized trial dubbed Mirror, Horizon demonstrated that patients on ...

Now new research, published at the ATS 2025 International Conference and in the American Journal of Respiratory and Critical Care Medicine, finds that methotrexate provides a comparable alternative.

Soon after she started taking the drug methotrexate in February, Jennifer Crow noticed a significant improvement in her inflammatory arthritis pain. Since then, she’s taken the drug weekly.

A recent open-label, uncontrolled trial found that adding tacrolimus to the regimen of patients with a suboptimal response to methotrexate could be beneficial. After 6 months' treatment ...