there is substantial evidence that the mismanagement of metal ion homeostasis contributes significantly to pathophysiological disorders of the central and peripheral nervous systems 7. Release of ...

A number of the compounds discussed in this section, and others that are known to interact with metal ion homeostasis, have been taken to the clinic and will be discussed in the following section.

We are focused on understanding pathways involved in metal/ion homeostasis and apoptosis as they contribute to disease (Alzheimer’s disease and cancer) or pathogenic processes (neurodegeneration). Our ...