In the '40s, DNA structure was still a puzzle ... The purine antagonist 6-mercaptopurine was among them. Elion found that she obtained an inhibitor of purine utilization when she substituted ...

Recent studies have shown that the incorporation of dG s TP into duplex DNA results in subtle localised modification on DNA structure (Somerville et al, 2003). Moreover, chromatin structure ...

Hikma is introducing mercaptopurine oral suspension, in a 20mg/ml dose, which is the first generic of this product. Hikma was the first approved applicant with a Competitive Generic Therapy ...

17–21 The present study was undertaken to identify some of the parameters of immune reactivity in man that might be affected by 6-mercaptopurine (6-MP), such as the antibody response to primary ...

Mercaptopurine is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL), but some patients cannot tolerate full doses of the drug. Another gene variant that strongly predisposes ...

Fig 2. Cumulative incidence of first relapse of acute lymphoblastic leukemia according to (A) taking mercaptopurine (6-MP) with food versus never with food; (B) taking 6-MP with milk or dairy products ...