In the '40s, DNA structure was still a puzzle ... The purine antagonist 6-mercaptopurine was among them. Elion found that she obtained an inhibitor of purine utilization when she substituted ...

Mercaptopurine is the mainstay of curative therapy for acute lymphoblastic leukemia (ALL), but some patients cannot tolerate full doses of the drug. Another gene variant that strongly predisposes ...

17–21 The present study was undertaken to identify some of the parameters of immune reactivity in man that might be affected by 6-mercaptopurine (6-MP), such as the antibody response to primary ...

emerged initially because of the important role this enzyme plays in metabolic transformation of the widely used anticancer and anti-inflammatory drugs mercaptopurine, thioguanine, and ...