The IV melphalan arm had a higher incidence of severe myelotoxicity (WBC ≤1,000 and/or platelets ≤25,000) vs the oral melphalan arm (28% vs 11%, respectively). Melphalan Injection Note ...

Melphalan hydrochloride belongs to a group of drugs called alkylating drugs.It’s available as a powder that is mixed into a solution for injection. It’s given as an intravenous (IV) infusion ...

It is recommended that Melphalan Hydrochloride be administered by injecting slowly into a fast-running IV infusion via an injection port, or via a central venous line.

Hypersensitivity reactions, including anaphylaxis, have occurred in approximately 2% of patients who received the IV formulation. Melphalan is leukemogenic in humans.

PURPOSETo review the clinical pharmacology and clinical trials that have used intravenous (IV) high-dose melphalan (HDM).METHODSWe reviewed the mechanism of action, clinical pharmacology, ... (stage ...

The current IV melphalan market is approximately $100 million annually, with predominant use in ASCT; EVOMELA is the only intravenous melphalan product that is approved for use in the high-dose ...

The researchers observed numerical differences consistently favoring the melphalan/HDS arm vs BAC in exploratory analyses of efficacy end points (median overall survival, 18.5 vs 14.5 months ...

Melphalan(Alkeran) generic is a chemotherapy agent, prescribed for multiple myeloma, melanoma, and ovarian carcinoma. It stops or slows the growth of cancer cells in the body.

Product has Potential to Offer Important Advantages Over Current IV Melphalan SAN DIEGO--(BUSINESS WIRE)-- Ligand Pharmaceuticals Incorporated (NASDAQ:LGND) today announced that it has made the ...

Die kumulativen Inzidenzraten der Graft-versus-Host-Disease (GvHD) der Grade II, III und IV kombiniert und der Grad-IV-GvHD betrugen in der Autotransplantat–Allotransplantat-Gruppe 43% bzw. 4%.

Oral melphalan and dexamethasone (MDex) ... (New York Heart Association class III or IV) heart failure and with N-terminal pro-natriuretic peptide type-B <8500 ng/l.