Silymarin (SM), App-Chem-Bio; China prepared in cream base of different concentrations ... randomized clinical study on patients with melasma attending the outpatient clinic of the Dermatology ...

"For melasma, retinol can be used as a stand-alone topical and is also commonly prescribed as a combination cream," says Dr.

Doctors often use hydroquinone as the first line of treatment for melasma. Hydroquinone is available as a lotion, cream, or gel. It works by lightening the color of the skin patches. A person can ...

[19] This may be the other mechanism of action of Silymarin in the treatment of melasma. Silymarin inhibited l-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme ...