"For melasma, retinol can be used as a stand-alone topical and is also commonly prescribed as a combination cream," says Dr.

Silymarin (SM), App-Chem-Bio; China prepared in cream base of different concentrations ... randomized clinical study on patients with melasma attending the outpatient clinic of the Dermatology ...

[19] This may be the other mechanism of action of Silymarin in the treatment of melasma. Silymarin inhibited l-DOPA oxidation activity of tyrosinase, the rate-limiting melanogenic enzyme ...