Hydroxyurea is an antineoplastic agent used most com-monly to treat both benign and malignant hematologic conditions. This medication inhibits ribonucleotide reductase to decrease DNA synthesis and ...

A longitudinal melanonychia, for example, is a brown or black vertical nail streak that’s typically benign. “It’s more likely that you have the benign streak. It’s a lighter streak.

Haneke E, Baran R: Longitudinal melanonychia. Dermatol Surg 2001; 27(6): 580-584. 4. Tosti A, et al: In situ melanoma of the nail unit in children: report of two cases in fair-skinned Caucasian ...

Melanonychia on only one nail may be concerning, especially in lighter-skinned individuals. If there is any concern for melanoma, referral for biopsy of the nail matrix is necessary.

Also, the cuticular seal of the nails should be intact, and the nail plate should adhere to the nail bed, says Dr. Thomas Stringer, a dermatologist with MedStar Health. “Fingernails, along with the ...

Pediatric longitudinal melanonychia should be treated differently from longitudinal melanonychia in adults, as lesions may grow darker or wider before stabilizing or improving, according to a ...

Your nails are made of a plate-like structure of specialized cells that grows out of a deep groove in the skin's dermis. ... known as linear melanonychia, may also run down the nail lengthwise.

The diagnosis and management of melanonychia — dark discoloring of the nail — can be challenging for clinicians as it is often benign but can be cancerous. News News CME CME ...

Further, Dr Zubritsky said that not all dark streaks on nails are subungual melanomas or dangerous. A longitudinal melanonychia, for example, is a brown or black vertical nail streak that's ...

Twenty-Nail Transverse Melanonychia. Simran Arinder Chadha, Parul Kathuria Goyal, Milena Lyon JCO Oncology Practice 2021 17: 4, 204-205. View Options. Login options. Check and see if you have full ...