Another possible mechanism of action is the preferential exertion of antibody- dependent cellular cytotoxicity on HER2-overexpressing cancer cells. [62] Trastuzumab contains an immunoglobulin G1 ...

Preclinical studies have indicated several molecular mechanisms that could contribute to the development of trastuzumab resistance. Increased signaling via the phosphatidylinositol 3-kinase/Akt ...

After preclinical studies suggested synergy between the two mechanisms of action, Byondis is now conducting a dose-escalation study of [vic-]trastuzumab duocarmazine combined with the PARP ...