Crystal structures of naturally produced antibiotics and their semi-synthetic derivatives bound to ribosomal particles have provided unparalleled insight into their mechanisms of action ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

A bacterial syringe delivers a deadly enzyme The mechanism of action of Tc toxins has only ... structure of the Tc toxin subunits and their assembly by cryo electron microscopy (cryo-EM) enabled ...

Antiinflammatory homeostatic mechanisms reverse these processes as the infectious agent is cleared by the innate and adaptive immune systems. The hypothalamic–pituitary–adrenal axis and ...

"We have found a new paradigm in the mechanism of action of the first identified ... both the autophosphorylation sequence and the assembly process of the active molecule, which acts as a kinase ...

By fusing two further cryo-EM snapshots of TccC3 bound to F-actin and of the modified F-actin alone, the scientists have uncovered the enzyme’s unique mechanism of action. “TccC3 acts like a boxer who ...