Explore a rare case of systemic mastocytosis in a young adult, highlighting its role in unexplained osteoporosis and the need for early testing.

A new case report was published in Oncoscience's Volume 12 on February 4, 2025, titled “Breaking point: Systemic mastocytosis manifesting as severe osteoporosis.” ...

The MAD cohort also saw adverse events such as hair loss and reductions in hemoglobin and neutrophil counts. These side ...

This blood test measures the level of tryptase, a protein mast cells produce. Genetic testing: Tests to identify specific genetic mutations, such as the KIT mutation, and help confirm the diagnosis.

Mast cell mediators, histamine, tryptase and NGF, released upon activation can excite sensory nerves and promote their growth. Corticotropin-releasing hormone, sensory nerves and the number of ...

Results from a skin biopsy confirmed a buildup of abnormal mast cells, a type of immune cell, and another test showed high levels of serum tryptase (a substance released by mast cells).

Third Harmonic Bio plans a Phase 2 trial for THB335 in chronic spontaneous urticaria and will reduce its workforce by 50% ...

Blood tests : Elevated levels of certain markers, such as tryptase (a protein released by mast cells), can suggest mastocytosis. Bone marrow biopsy : A sample of bone marrow is taken to check for ...

Mediators of anaphylactic reactions:- Aside from mast cell tryptase, which other chemical inflammatory mediators offer potential as indicators of anaphylaxis? Why this is important:- Although mast ...

Third Harmonic Bio (THRD) announced results from its Phase 1 single and multiple ascending dose clinical trial of THB335 in healthy volunteers.

This report highlights the diagnostic challenges of SM, emphasize its underrecognized role in osteoporosis and fragility fractures, and advocates for ...