While the precise mechanism of action is unclear ... especially the central nervous and cardiopulmonary systems, local anesthesia has more confined, site-specific effects. Like general anesthesia ...

Despite the physiological importance of sodium channels and their possible role as general anesthetic targets, little is known about interaction sites or the mechanism of action. Penn's Roderic ...

Their primary site of action is in the central nervous system, where they inhibit nerve transmission by a mechanism distinct from that of local anesthetics. The general anesthetics cause a ...

"Beyond suggesting a mechanism of anesthetic action, this discovery is of great clinical importance because it suggests that brain states under general anesthesia can be monitored using the EEG on ...

The research demonstrates a way to control the spread of the toxin and harness it into an effective local anesthetic that ... It is this exact mechanism that has attracted scientists looking ...

Lidocaine is a commonly used local anesthetic that works by blocking signals at the nerve endings in the skin. It is often used in the form of a topical cream or injection. However, recent ...

However, understanding the role of intravenous anesthetics on the LC-NE system and the synaptic mechanisms involved remained rudimentary. To better understand the action of intravenous anesthetics ...

There are several uses of these agents and at present there are two major uses – as an agent that induces general anesthesia ... The primary mechanism of action of barbiturates is inhibition ...

Liposomal bupivacaine was launched on the market 12 years ago to provide long-lasting local control of pain. The medication is used as a local anesthetic ... Its mode of action is based on ...

The injections typically used to apply local ... action could make it suitable for wide clinical use," they write. Future studies should compare the tablets head-to-head with other topical ...