MDA is the most mutagenic product of lipid peroxidation and is commonly used ... expression and a cytotoxic promoter of pathological pathways. Cancer cells have increased levels of reactive ...

The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a ...

It is mediated by iron molecules, with the cell dying through the degradation of the phospholipid bilayer by oxidation, a process called lipid peroxidation. However, recent studies have shown that ...

Ferroptosis is triggered by the iron-mediated production of reactive oxygen species (ROS) and subsequent lipid peroxidation, which plays a crucial ... and signals that make this alternative cell death ...