The investigators then demonstrated that the dysregulation of this metabolic pathway led to increased lipid peroxidation—a process that damages cellular membranes and may trigger neuronal death.

Detection of lipid peroxidation. Placentas obtained from pregnant rats (n = 6) were homogenized in PBS, centrifuged at 10,000× g for 60 min and supernatants were used for analysis. MDA was ...