The Bls reaction begins with activation of the substrate, carboxyethylarginine, by aminoadenylation using ATP, followed by closure of the β-lactam ring to give the monocyclic intermediate ...

Successful synthesis of gamma-lactam rings from hydrocarbons. ScienceDaily. Retrieved May 31, 2025 from www.sciencedaily.com / releases / 2018 / 03 / 180301144145.htm. Institute for Basic Science.

video: This is a successful synthesis of Gamma-Lactam rings from Hydrocarbons_IBS. view more Credit: Institute for Basic Science( IBS) A team of researchers at the Center for Catalytic Hydrocarbon ...

Top: β-lactam antimicrobial agents rupture bacteria by destroying their cell walls. Bottom: The red text in the structural formula represents the β-lactam ring, which is essential for ...

Crosslinking is prevented by β-lactam antibiotics, leaving the bacterial cells susceptible to attack. 1, 2 But a naturally occurring enzyme β-lactamase can hydrolyze the β-lactam ring ...

Cysteine Hydropersulfide Inactivates β-Lactam Antibiotics with Formation of Ring-Opened Carbothioic S-Acids in Bacteria. ACS Chemical Biology, 2021; 16 (4): 731 DOI: 10.1021/acschembio.1c00027; ...