The first workflow is an efficient computational approach for in silico KIR probe interpretation (KPI) to accurately interpret individual’s KIR genes and haplotype-pairs from KIR sequencing reads. The ...

KIR haplotypes fall into two broad categories: group A haplotypes have a restricted gene content of 2DL1, 2DL3, 2DL4, 3DL1, 3DL2, 3DL3, 2DS4, 2DP1 and 3DP1 genes, whereas group B haplotypes may ...

We hypothesized a possible KIR-driven pressure in the genesis of specific HLA-A,B haplotypes. Certain HLA-A and -B molecules are ligands for the same KIR receptors through the Bw4 binding motif ...

[162,164] KIR A haplotypes have simple, fixed gene content. KIR B haplotypes have variable gene content and one or more of the B-specific genes: KIR2DS-1, -2, -3, -5, KIR2DL2, and KIR2DL5.

These patients showed lower PFS rates compared to 19/53 patients with high affinity FCGR polymorphisms (p < 0.01). Importantly, ADCC analysis on day 15 of cycle 1 showed higher levels in the pt group ...

Analysis of the KIR gene complex has led to the recognition of a series of KIR gene haplotypes that can be divided into two major groups, each containing distinctive sets of KIR genes in their ...

Specific combinations of donor KIR and patient HLA genes are associated with improved hematopoietic stem cell transplantation (HSCT) outcomes for patients with acute myeloid leukemia.