Phosphorylation can either activate a protein (orange) or inactivate it (green). Kinase is an enzyme that phosphorylates proteins. Phosphatase is an enzyme that dephosphorylates proteins ...

Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation ...

An unexplored kinase in heart muscle cells may be a good target to treat heart failure, ... the HIPK2 deficiency and apoptosis signaling acted via decreased ERK1/2 kinase phosphorylation.

Thus, future phosphorylation studies should be targeted at not only definitively linking a phosphorylation event to its cognate kinase in vivo, but also mapping more time- and condition-specific ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. ... (*1) Protein phosphorylation.

Next-generation protein kinase inhibitors have the potential to revolutionize cancer therapy. Clinical trials have already shown extremely promising results, with next-generation inhibitors ...

Location, location, location: in situ phosphorylation screen reveals novel cell cycle kinase substrate landscape From the Clurman Laboratory, Human Biology and Clinical Research Divisions. May 18, ...