The ability of protein kinases to transfer a phosphate group to target proteins plays an important role in many cellular ...

Phosphorylation can either activate a protein (orange) or inactivate it (green). Kinase is an enzyme that phosphorylates proteins. Phosphatase is an enzyme that dephosphorylates proteins ...

Thus, future phosphorylation studies should be targeted at not only definitively linking a phosphorylation event to its cognate kinase in vivo, but also mapping more time- and condition-specific ...

Polo-like kinase 1 (Plk1) controls multiple aspects of mitosis and is activated through its phosphorylation at Thr210. Here we identify Ser99 on Plk1 as a novel mitosis-specific phosphorylation ...

Understanding neural protein phosphorylation and the role of different kinases and substrates is now made easier by the newly developed data repository, KANPHOS Signal transduction, or cellular ...

The study uncovers a novel mechanism by which ING5 promotes the phosphorylation of pyruvate dehydrogenase kinase 1 (PDK1) at tyrosine 163 (Y163), thereby inhibiting the Warburg effect and reducing ...

A research group has discovered that in mammals, a protein kinase A (PKA) promotes wakefulness, while protein phosphatase 1 (PP1) and calcineurin promote sleep. ... (*1) Protein phosphorylation.

Location, location, location: in situ phosphorylation screen reveals novel cell cycle kinase substrate landscape From the Clurman Laboratory, Human Biology and Clinical Research Divisions. May 18, ...

Next-generation protein kinase inhibitors have the potential to revolutionize cancer therapy. Clinical trials have already shown extremely promising results, with next-generation inhibitors ...