A rare SIK3 gene mutation may explain why some people need less sleep yet maintain optimal cognitive function and physical ...

Without 8 or 9 hours of sleep, most of us end up staggering around like zombies. But according to a new study, some people have a genetic mutation that makes them feel perfectly alive after sleeping ...

the amino acid residues must be in certain places relative to one another for the kinase to function. A sequence of amino acids in the kinase domain, referred to as the activation loop ...

It is no surprise then that academic labs and pharmaceutical companies are hot on the trail of understanding kinase function. Kinases impart their signal by transferring the γ-phosphate group ...

Scientists have recently made a major breakthrough in medical genetics with the discovery of a new autoinflammatory disease ...

As such, platforms that look at the function of proteins, so-called “functional proteomics,” are desperately needed for kinase-targeted therapies. The Kinome Core represents a functional proteomic ...

Abnormal kinase signaling can promote other harmful traits, such as neuroinflammation and neuronal cell death. On the other hand, the loss of function in certain kinases has been identified as a ...