Irreversible changes are permanent. They cannot be undone. For example you cannot change a cake back into its ingredients again. A change is called irreversible if it cannot be changed back again.

Afatinib is an irreversible kinase inhibitor that blocks ... which is also developing covalent inhibitors. “It's a nice example of where a covalent inhibitor can serve patients.” ...

We predict that this network will eventually also prove to be dynamically irreversible, due to feedback signals that create a bistable switch. In the examples described, irreversible transit ...