The cell must also pass through a series of checkpoints that ensure conditions are favorable for division. In order to move from one phase of its life cycle to the next, a cell must pass through ...

scientists have constructed a new threshold model of cell cycle control. Accordingly, either CDK1 or CDK2 bound to cyclin A is sufficient to control interphase, whereas cyclin B-CDK1 is essential ...

Drugs such as these could be substantially less effective if there was also a DNA damage checkpoint in mitosis. The aim of my research is to understand what happens when a cell with damaged DNA ...