Here we discuss some of the effects of insulin resistance and mechanisms of potentially detrimental influence of hyperinsulinemia in the presence of metabolic insulin resistance. The term "insulin ...

Now, a study published in Cell Communication and Signaling describes new molecular mechanisms to understand insulin resistance in skeletal muscle and to outline future drug targets for DM2.

Focusing on insulin resistance, several important questions ... have greatly advanced our understanding of the molecular and biochemical mechanisms that are involved in the development of type ...

A newly discovered mechanism that leads to liver dysfunction may be a key factor in type 2 diabetes and other metabolic ...

Identifying proteomic signatures of insulin resistance in fasting muscle offers insights for personalized type 2 diabetes ...

The cellular mechanisms causing insulin resistance are far from fully understood ... at the Université de Montréal and Director of the Molecular Physiology Research Unit at the Montreal Clinical ...

However, managing insulin resistance is crucial to preventing the progression to type 2 diabetes. A number of studies have shed light on the molecular mechanisms underlying insulin resistance.

Insulin resistance precedes and predicts the onset ... The results of this study identify new mechanisms by which PPARβ/δ regulates InsRβ protein levels in skeletal muscle.

Based on these data we hypothesize the following. Compensatory hyperinsulinemia that accompanies insulin resistance generates either a normal or a stronger-than-normal initial signal at the level ...