How might the immune system take advantage of the B cell synapse to optimize the effectiveness of encounters between B cells and soluble toxin or circulating viruses? The answer may lie ...

Investigators from Baylor College of Medicine, Texas Children’s Cancer Center and the Center for Cell and Gene Therapy at Baylor, Houston Methodist Hospital and Texas Children’s Hospital examined how ...

In recent years growing attention has been directed towards the molecular mechanisms that are shared by the nervous and immune systems ... might have a role in synapse elimination, the authors ...

The interaction between CD2 and CD58 is critical for forming the immunological synapse, which is pivotal in immune cell activation and adhesion, as well as signaling in both immune and target cells.

Led by first author Dr. Ahmed Gad, postdoctoral associate in Ahmed's lab, the research team examined molecular dynamics at the immune synapse. The team biopsied the CAR T cell immunological ...

CTLs and NK cells kill by forming a stereotyped interface with their targets, known as a cytolytic immunological synapse, into which they secrete a mixture of toxic perforin and granzymes. Our ...