is determined by demonstration of a monoclonal immunoglobulin molecule or chain in serum and/or urine. Previous results on immunofixation electrophoresis (IFE) and quantitative free light chain ...

His self-torture—and that of peers around the globe who would likewise offer up their own skin for experiments—would ultimately lead to the discovery of immunoglobulin E (IgE), an antibody responsible ...

The following is a summary of “Gain or amplification of 1q21 in systemic light chain amyloidosis is associated with advanced Mayo stage, plasma cell disease and worse overall survival,” published in ...

Background: Monoclonal free light chains (FLCs) frequently cause rapidly progressive renal failure in patients with multiple myeloma. Immunoassays which provide quantitative measurement of FLCs in ...

Ingrid Haas (BZH, Heidelberg) presented data implicating mannose trimming in the proteasome-mediated degradation of an immunoglobulin κ-light-chain engineered to contain one or two glycosylation ...

Paradox is focused on the development of treatment for immunoglobulin light chain amyloidosis (AL amyloidosis), a complication of multiple myeloma that can lead to heart, kidney and liver failure ...