Fig 1. Prognostic relevance of hematologic response in the test cohort. (A) Survival from the 6-month landmark of 649 patients with immunoglobulin light chain (AL) amyloidosis based on hematologic ...

However, it is well documented that plasma cells also produce and secrete Ig-free light chain (IgLC) in excess over Ig heavy chains 5,6,7,8. Turnover studies in humans demonstrated that only 60% ...

Systemic immunoglobulin light-chain (AL) amyloidosis is characterized by deposition of amyloid fibrils of light chains produced by clonal CD38+ plasma cells. Daratumumab, a human CD38-targeting ...

The study of intraclonal diversification (ID) in immunoglobulin (IG ... Multiple analogies were noted between heavy and light chains regarding the occurrence and molecular features of ID.

Care of patients with systemic immunoglobulin light chain (AL) amyloidosis has undergone transformative changes, leading to marked, steady progress in outcomes for patients over the past four decades.

Immunoglobulin light chain amyloidosis (AL amyloidosis) results from the tissue deposition of amyloid fibrils derived from monoclonal immunoglobulin (M-Ig) light chains (LCs) produced by an indolent ...

This initiative celebrates important research from the School of Medicine faculty members. Recently, his study “Immunoglobulin light chains generate pro-inflammatory and profibrotic kidney injury,” ...

really small… this “M-protein” the dominant-overpowering antibody (immunoglobulin) is composed of two different kinds of molecules, the two “chains”; Heavy Chain Molecules and Light Chain Molecules.

Histopathology of intraoral lesions revealed hematic extravasation and λ light chain deposition on the capillary endothelium. A hematologist performed a bone marrow biopsy, which was diagnostic for ...

Light chain multiple myeloma is a subtype of multiple ... The type depends on the immunoglobulin that a myeloma cell produces, also known as antibodies or M-proteins. According to the ...