Figure 1: Kinase targets in clinical trials and the currently targeted kinome. To evaluate the diversity of kinase targets studied in preclinical and early kinase drug discovery projects ...
Imatinib mesylate is a tyrosine kinase inhibitor used in the treatment of cancers including chronic myeloid leukemia. In their study, however, Kerkelä et al. report that this drug can be ...
In the PamStation®12 system, active kinases within a cellular/tissue lysate will phosphorylate specific peptide substrates within the microarray which survey the particular kinome (tyrosine or ...
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