The deletion of mesenchymal RANKL impairs M cell–dependent antigen sampling and B cell–dendritic cell interaction in the SED, ... IgM + and IgA + cells in CD45 + CD3 ...

Gut-associated lymphoid tissues are responsible for the generation of IgA-secreting cells. However, the function of the caecal patch, a lymphoid tissue in the appendix, remains unknown. Here we ...

Mucosal immune surveillance is thought to be largely achieved through uptake by specialized epithelial M cells. We recently identified Claudin 4 as an M cell target receptor and developed a Claudin 4 ...

This form of IgA occurs selectively in saliva, colostrum, ... Pringault, E, ed. M cell development and function in physiology and disease. Semin Immunol 1999;11:155-224. Crossref.

Multiple myeloma affects plasma cells. It can cause a spike in M proteins, ... Occasionally, traditional methods may not detect IgA myeloma, so it may not show up as an M spike.

Healio has compiled a list of its most-read nephrology care news in 2023. Readers were most interested in proteinuria and GFR results with a new IgA nephropathy drug, stem cell transplantation to ...

For example, a serum factor, probably a lectin, present in patients with IgA nephropathy, induces expression of interleukin-6 by peripheral mononuclear cells. 53 Lectins can also promote ...

Pietro A. Canetta, MD, MS, reflects on a particularly impactful case involving a young professional with IgA nephropathy, who was diagnosed after showing mild proteinuria and hematuria. Despite a ...