Then the chemists destroy the enzyme and use light to switch to the E isomer of the hydrazone, which no longer fits within γ-cyclodextrin. “We don’t need steam distillation,” Aprahamian says.

Synthesis Hydrazone performs cross-coupling twofer Bench-stable reagent acts as a cyclopropylcarbinyl equivalent, producing either skipped dienes or vinyl cyclopropanes ...

However, the classic Fischer indole synthesis produces a mix of both enantiomers. ... During the reaction, a chiral hydrazone is first formed as an intermediate in both enantiomeric forms.

Enantioselective synthesis of indole derivatives Date: April 8, 2021 ... The other hydrazone enantiomer reacts very slowly and leads to only a small amount of the indole product.