A drug–drug interaction between brivudin and capecitabine caused medullar aplasia, serious toxic effects to the intestinal mucous membrane, hand-foot syndrome, onycholysis and dental pigmentation.

Possible explanations for this subsequent lack of effect of capecitabine on AUC might include reduction in doses due to initial toxic events, such as hand–foot syndrome requiring analgesics or ...

Sorafenib-plus-capecitabine is associated with a high incidence of grade 3 hand–foot syndrome/skin reaction (45%). Sorafenib-plus-paclitaxel demonstrated a statistically significant improvement ...

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