Possible explanations for this subsequent lack of effect of capecitabine on AUC might include reduction in doses due to initial toxic events, such as hand–foot syndrome requiring analgesics or ...

In the past 5–10 years there has been a growing trend for substituting conventional 5-fluorouracil with the oral prodrug of 5-fluorouracil, capecitabine, in chemotherapy regimens. This regimen ...