But even though the reaction was first described 120 years ago, chemists have only now uncovered the details of its complex mechanism (J. Am. Chem. Soc. 2020, DOI: 10.1021/jacs.9b11829) ...

The stereoselective addition of Grignard reagents to ketimines is potentially a straightforward route to α-chiral amines. Here the authors report a catalytic, asymmetric Grignard addition to ...

Aromatic ketones have long been valuable intermediates in chemical synthesis, particularly in cross-coupling reactions where different chemical entities are combined to form new compounds. For ...

The Grignard reaction is a classic reaction in organic chemistry, useful for building the carbon skeleton of molecules by transforming carbon-halogen bonds into carbon-carbon bonds. Fluorine is also ...