Glucagon increases the production of glucose by increasing glycogenolysis and gluconeogenesis in the liver, and by reducing glycogenesis and glycolysis. The release of glucagon in response to food ...

Figure 2: Activation of the glucagon receptor and PKA signaling pathway are required for MBH glucagon to lower HGP. Figure 3: Glucagon action in the MBH lowers HGP through the hepatic vagus and ...

Scientists have discovered that cells in the pancreas cooperate -- signal -- in a way hitherto unknown. The discovery can eventually be of significance to the treatment of diabetes. Scientists at ...

They also present new opportunities for drug discovery by designing biased ligands to selectively block one specific signaling pathway, thus resulting in reduced side effects. Structural basis of Gs ...

by interfering with the intracellular location and signaling pathways of glucagon receptor, thereby reviving glucagon antagonism as potential treatment for type 2 diabetes. Need for novel ...

(NEW YORK, NY, April 12, 2012) —Maintaining the right level of sugar in the blood is the responsibility not only of insulin, which removes glucose, but also of a hormone called glucagon ...

However, direct stimulation of the protein kinase A signaling pathways (PKA) in the brain bypasses the resistance and decreases blood sugar levels. The study, entitled "Hypothalamic glucagon ...

More than 90% of patients achieved clinically meaningful weight reduction compared to placebo in a phase 3 trial of ecnoglutide.

Insulin and glucagon are hormones produced in the ... amino acids (from protein diets), through Rab1A-mTOR nutrient signaling pathway, also control these endocrine hormones. We also found that ...

In this context, glutamate acts as a positive signal that tells the alpha cells that it is time to accelerate the production of glucagon to prevent glucose levels from falling too low.

They also present new opportunities for drug discovery by designing biased ligands to selectively block one specific signaling pathway, thus resulting in reduced side effects. Structural basis of Gs ...