The patient underwent genetic testing to confirm the diagnosis of Mahvash disease, and germline sequencing of GCGR revealed two variants (NM_000160.5:c.247del and NM_000160.5:c.463del) that ...

image: Structures of the human glucagon receptor GCGR involved in glucose homeostasis view more . Credit: Image by WU Beili's laboratory at SIMM. G protein-coupled receptors (GPCRs) are essential ...

Genetic inactivation of the kidney glucagon receptor (GCGR) in mice causes abnormalities in renal health and metabolic dysregulation, with symptoms resembling those of chronic kidney disease (CKD ...

DA-1241 is a novel G-Protein-Coupled Receptor 119 ... (GLP1R) and glucagon receptor (GCGR) dual agonist. OXM is a naturally-occurring gut hormone that activates GLP1R and GCGR, ...

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), has become the most prevalent chronic liver disease globally.

As previously reported, with no titration, DA-1726, with its novel 3:1 ratio between GLP-1R and GCGR at the 32 mg dose, demonstrated compelling maximum weight loss of -6.3% and mean weight loss of ...

SAN FRANCISCO and SUZHOU, China, Sept. 1, 2024/ PRNewswire/-- Innovent Biologics, Inc., a world-class biopharmaceutical company that develops, manufactures and commercializes high-quality ...