Multiple gastrointestinal stromal tumors typically occur in familial form associated with KIT receptor tyrosine kinase or platelet-derived growth factor receptor-alpha (PDGFRA) germline mutations ...

Gastrointestinal stromal tumor is the most common neoplasm of mesenchymal origin, 1 with an annual incidence of approximately 6,000 cases in the United States. Most cases are driven by oncogenic KIT 2 ...

Gastrointestinal stromal tumor is the most common mesenchymal neoplasm of the gastrointestinal tract. Mutually exclusive KIT or platelet-derived growth factor receptor-α mutations are key events ...

Gastrointestinal Stromal Tumors: Study May Result In More Targeted Drugs Date: November 24, ... Ph.D., vice chairman for research and professor of pathology and OHSU Knight Cancer Institute member.

Gastrointestinal stromal tumors (GISTs): definition, occurrence, pathology, differential diagnosis and molecular genetics. Polish journal of pathology : official journal of the Polish Society of ...

Gastrointestinal stromal tumors are a group of mesenchymal neoplasms that arise from precursors of the connective-tissue cells of the gastrointestinal tract. 1 They occur predominantly in middle ...

In summary, radical surgery is the treatment of choice for operable GISTs. Very low- and low-risk diseases can be treated with surgery alone. Lymph node metastasis is rare in GIST patients and may ...

More information: Feifei Xie et al, Genomic and transcriptomic landscape of human gastrointestinal stromal tumors, Nature Communications (2024). DOI: 10.1038/s41467-024-53821-1. Provided by BGI ...

Most advanced gastrointestinal stromal tumors (GISTs) start with cancer-causing cell changes, or mutations, in specific genes. Changes in proteins called KIT and PDGFRA most commonly cause this ...