Gamma-lactams find several applications in medicinal, synthetic, and material chemistry. For example, they are included in a large number of pharmaceutically active compounds with antibiotic, ...

Gamma-lactams find several applications in medicinal, synthetic, and material chemistry. For example, they are included in a large number of pharmaceutically active compounds with antibiotic, ...

The enzyme developed in Arnold’s lab can create beta-lactam, gamma-lactam, and delta-lactam molecules. Credit: Caltech “In traditional synthetic chemistry, we have to tack extra reactive groups onto ...

In the 1990s, the lab of Frances Arnold showed how we can turn evolution to our advantage by manipulating microbes into evolving in a certain way. Now Arnold's team is using the technique to ...

Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression).

BMS-561392 is a gamma-lactam analog of the nonpeptide, small-molecule selective TACE inhibitor IK682. In animal models, it functions as a DMARD.

May 10 (UPI) --Scientists have developed a better way to build new antibiotics. Using a method known as directed evolution, researchers successfully synthesized beta-lactams, a molecular structure ...

Figure 3: Interesting gamma-lactams derived from natural and unnatural amino acids, steroids, etc., which may be used to protect plants against insects, fight parasitic worms, or as anti-aging agents.

Das applied the photocatalytic strategy in his study to synthesise gamma-lactam, a compound used in antibiotics, anti-inflammatory and anti-cancer pharmaceuticals.

The isolation of Lipid II, accumulated as a result of chemical probe treatment, enables the reconstitution of crosslinked peptidoglycan biosynthesis and a direct transpeptidase assay for PBP2 ...

De-escalation of beta-lactam antibiotics was associated with a decreased risk of new resistance development compared with no change in beta-lactam antibiotic use, researchers found.