Gamma-lactams find several applications in medicinal, synthetic, and material chemistry. For example, they are included in a large number of pharmaceutically active compounds with antibiotic, anti ...

Gamma-lactams find several applications in medicinal, synthetic, and material chemistry. For example, they are included in a large number of pharmaceutically active compounds with antibiotic, ...

The enzyme developed in Arnold’s lab can create beta-lactam, gamma-lactam, and delta-lactam molecules. Credit: Caltech “In traditional synthetic chemistry, we have to tack extra reactive groups onto ...

Gamma-lactams (cyclic molecules that are common in antibiotics) were easily synthetically accessible from alpha, beta-unsaturated amides (an important molecule in cancer progression).

Researchers also evolved two other enzymes to produce different sized lactams, a gamma-lactam and delta-lactam, which are different-sized loops featuring different combinations of nitrogen and ...

In the 1990s, the lab of Frances Arnold showed how we can turn evolution to our advantage by manipulating microbes into evolving in a certain way. Now Arnold's team is using the technique to ...

[21] BMS-561392 is a gamma-lactam analog of the nonpeptide, small-molecule selective TACE inhibitor IK682. [31] In animal models, it functions as a DMARD. BMS-561392 originated at Dupont-Merck and ...

Figure 3: Interesting gamma-lactams derived from natural and unnatural amino acids, steroids, etc., which may be used to protect plants against insects, fight parasitic worms, or as anti-aging agents.

Das applied the photocatalytic strategy in his study to synthesise gamma-lactam, a compound used in antibiotics, anti-inflammatory and anti-cancer pharmaceuticals. Through this mechanism ...

β-lactam antibiotics target the final stages of peptidoglycan biosynthesis by inhibiting the transpeptidases that crosslink glycan strands to complete cell wall assembly. Characterization of ...

De-escalation of beta-lactam antibiotics was associated with a decreased risk of new resistance among patients with sepsis. Limiting exposure to the shortest effective duration could curb resistance.