First, GABA is initially excitatory. Second, GABA synapses are formed before glutamatergic ones. Third, the excitatory actions of GABA generate a primitive pattern of activity, which helps to ...

Surprisingly, GABA is not be involved in initial synapse formation, however, but rather in pruning them back, a process analogous to speed dating. Quite early in its development, the mammalian ...

They were able to control the availability of GABA at the synapse by manipulating the concentration of its amino acid precursors in the bath in which the cells were recorded. They could also block ...

The neurotransmitters GABA and glycine, on the other hand, transmit an inhibitory message, telling the subsequent cell not to fire. At excitatory synapses, Prof. Takahashi's group has previously ...

Yale researchers used light to probe the actions of the neurotransmitter GABA on single synapses along the branches of a neuron. The work, appearing in the May 10 issue of the journal Science, ...

These findings show that glutamate activates distinct receptors and patterns of calcium signaling for opposing control of inhibitory GABA synapses. Notes Bannai, "it was surprising that the same ...

Nearly half of all synapses of the brain express some kind of GABA receptor. GABAA receptors are widely but differentially distributed within the CNS and they can be activated by several GABA ...

that GABA neurons in the VTA may have a direct connection with the synapses of local DA neurons. The putative mechanism underlying this relationship was highlighted by light-activation of GABA ...

Weiner's work focuses on what is called the GABA synapse which he says contributes to many of alcohol's behavioral and cognitive effects, especially intoxication, dependence and withdrawal.

That much they had anticipated. The unexpected observation was that GABA proved not to be involved in the initial formation of these tentative or "test" synapses, but rather in the essential ...