Mutant huntingtin abnormally interacts with the mitochondrial fission GTPase dynamin-related protein-1 (DRP1) in mice and humans with Huntington's disease, which, in turn, stimulates its enzymatic ...

Ras proteins are normally tightly regulated by factors that switch off the GTPase activity. ... (NF1) gene codes for a Ras GTPase activating protein that causes neurofibromatosis type 1.

Direct detection of GDP for monitoring GTPase, GAP, and GEF activity; Easy to use, two-step format (no coupling enzymes needed) Far-red fluorescent readouts reduce compound interference; ...

Bristol Myers Squibb Co. has identified new GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer.

(HealthDay News) — The R-enantiomer of ketorolac is enriched in peritoneal fluids and inhibits peritoneal cell GTPase activity with administration after ovarian cancer surgery, according to a ...

AF6 denotes afadin, GAP GTPase-activating protein, GEF guanine exchange factor, MEK mitogen-activated protein kinase kinase, MT mutant, Pi inorganic phosphate, P13K phosphoinositide 3-kinase ...