This is a preview. Log in through your library . Abstract Insulin-activated glucose transport depends on the efficient sorting of facilitated hexose transporter isoforms to distinct subcellular ...

The process of GLUT4 trafficking is central to the metabolic regulation of blood glucose levels. In both muscle and adipose cells, the insulin hormone triggers the mobilisation of intracellular ...

This is a preview. Log in through your library . Abstract The functional trafficking steps used by soluble NSF attachment protein receptor (SNARE) proteins have been difficult to establish because of ...

In normal myocytes, insulin treatment activates glucose uptake to the muscle by promoting the cell surface delivery of cytoplasmic storage vesicles that contain the glucose transporter GLUT4. Like ...

Muscle GLUT4 concentrations were expressed relative to the corresponding baseline values that were set equal to 1 (Fig. 1). Muscle GLUT4 content at baseline was similar between the groups. In the ...

The common forms of type 2 diabetes are caused by a constellation of genetic and epigenetic factors and molecular changes related to diet; lifestyle, including lack of exercise and sleep; ...

* Regular fish oil supplementation lowers type 2 diabetes risk in prediabetics * Omega-3s enhance muscle sugar metabolism via key enzymes and GLUT4 translocation * EPA omega-3 shows a //stronger blood ...

Insulin resistance has a causal role in type 2 diabetes. Serum levels of retinol-binding protein 4 (RBP4), a protein secreted by adipocytes, are increased in insulin-resistant states. Experiments in ...

Type 2 diabetes (T2D) has become one of the leading chronic diseases worldwide in terms of both incidence and mortality. According to the International Diabetes Federation (IDF), approximately 537 ...

A total of 13 men and 9 women, aged 20-23 years, gave their informed written consent to participate in the study. They were instructed to abstain from taking any medication and to avoid making any ...