CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...

The G1–S transcriptional programme is robustly activated by positive feedback mechanisms, creating an 'all-or-none' switch that leads to cell cycle commitment. Inactivation of G1–S ...

The stages of this cycle include: Gap 1 (G1) phase, DNA synthesis ... M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint. They aid the formation ...

These biochemical pathways have been termed "checkpoints ... In summary, "CDK4/6 is a key mediator of cell cycle progression through the G1 phase, the time when a cell prepares to initiate ...

In essence, cell cycle arrest at these critical checkpoints represents a survival mechanism ... are separated by gaps of varying length called G1 and G2 (Fig 1 Fig 1. The cell cycle and the response ...

Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic ...

This sequential expression followed the phases of the traditional cell cycle: G0/G1 (the cell grows larger), S (the cell replicates its DNA), and G2/M (the cell prepares for division and then splits).

Cyclin D and CDK4/6 play a key role in cell-cycle progression by phosphorylating and inactivating the retinoblastoma protein, a tumor suppressor that restrains G1- to S-phase progression. The ...

The gene p21CIP1/WAF1 inhibits the proper functioning of cyclin-dependent kinases (CDKs), molecules that help to control cellular duplication. Although p21CIP1/WAF1 is known to be regulated by the ...