CDKs function to phosphorylate many different proteins which are required for passing important points in the cell cycle, called checkpoints. These checkpoints are present at the end of G1 and the ...

The G1–S transcriptional programme is robustly activated by positive feedback mechanisms, creating an 'all-or-none' switch that leads to cell cycle commitment. Inactivation of G1–S ...

The stages of this cycle include: Gap 1 (G1) phase, DNA synthesis ... M cyclins increase in mitosis and fall once the cell has passed the spindle formation checkpoint. They aid the formation ...

In essence, cell cycle arrest at these critical checkpoints represents a survival mechanism ... are separated by gaps of varying length called G1 and G2 (Fig 1 Fig 1. The cell cycle and the response ...

Background: Targeting cell cycle checkpoints has the potential to enhance the efficacy of chemoradiation therapy. Tumor cells commonly have an abnormal G1 checkpoint due to mutations in the p53 ...

Claudia Waskow at the Carl Gustav Carus Faculty of Medicine at Dresden Technical University is now describing a new mechanism in which the length of the G1 phase of the cell cycle has a dramatic ...

A hallmark of tumor cells is an inability to control their proliferation, which implies that these cells are capable of bypassing cell cycle checkpoints and regulation by tumor suppressor signaling ...

The gene p21CIP1/WAF1 inhibits the proper functioning of cyclin-dependent kinases (CDKs), molecules that help to control cellular duplication. Although p21CIP1/WAF1 is known to be regulated by the ...